1. Route 66 (1960-64) - One of the most iconic cars in American pop culture, the Corvette driven by Tod Stiles (Martin Milner) was the only possession his deceased father left him--other than a lot of bills. There were actually several models and colors of Corvettes used in the series (Chevrolet was a sponsor). For all but one episode of the first season, Tod and Buz (George Maharis) cruised the country in a blue 1960 'Vette. Still, it looked gray since the series was filmed in black and white!
3. Batman (1966-68) - Sure, the movie incarnations of the Batmobile may look sleeker, more realistic, and boast more gadgets--but the '66 version was considered pretty cool for its time. Customized from a 1955 Lincoln Futura (a concept car), the Batmobile was a staple at touring auto shows for years. Today, it is estimated to be worth $2 million.
4. The Dukes of Hazzard (1979-86) - While Bo, Luke, and Daisy may have gotten more fan mail, the "General Lee"--the boys' 1969 Dodge Charger--was mighty popular. With a Confederate flag on its roof and a horn that played "Dixie," it sure had a Southern vibe. Over 200 General Lees were used during the filming of the series. The doors were welded shut for the stunts--though it looked cool, too, when Bo and Luke climbed in and out of the windows.
5. UFO (1970) - Most of the vehicles in Gerry Anderson's futuristic series were nifty miniatures, but the car driven by Commander Ed Straker was a modified Ford Zephyr Mark IV with doors that open upward. Although probably the least-known auto in our Top 5, it has a cult following among pop culture car enthusiasts and Dinky Toys even marketed a die-cast miniature called, appropriately, Ed Straker's Car. For a few years, it was owned by a BBC Radio 1 disc jockey.
Honorable Mentions: 1975 Ford Gran Torino from Starsky & Hutch; 1978 Ferrari 308 GTS from Magnum, P.I.; 1974 Pontiac Firebird Esprit from The Rockford Files; the "Black Beauty" from The Green Hornet; and Emma Peel's Lotus Elan from The Avengers.