4. Run for Your Life (1965-68). Ben Gazzara played Paul Bryan, a successful lawyer who learns that he has a terminal illness and only two years to live. He quits his job and goes on the road to live life to its fullest. This TV series was spun off from the episode “Rapture at Forty-Two” on the anthology series Kraft Suspense Theater. Gazzara received Emmy nominations for two of the series’ three seasons. Martin Milner from Route 66,guest starred on a couple of the episodes. Roy Huggins, who created The Fugitive (and many other shows), produced Run for Your Life.
5. The Loner (1965-66). Rod Serling created this "adult Western" that downplayed action in favor of human interest stories. Like The Twilight Zone, the series had a social conscience, this time in the form of hero William Colton (Lloyd Bridges), a former Union officer searching the West for a meaningful existence. This wasn’t the first Western about a drifter nor the last. Nick Adams played an ex-Confederate soldier roaming the West in The Rebel (1959-62), which featured a title tune sung by Johnny Cash. In the late 1960s, Walter Brennan and Dack Rambo looked for Dack’s father (who abandoned his son as an infant and became a gunfighter) in The Guns of Will Sonnett.
Honorable Mentions: Then Came Bronson with Michael Parks (in a role not unlike Buz on Route 66) riding his motorcycle throughout the country; The Immortal with Chris George as a race car driver being pursued by those who want his blood—literally, because it contains antibodies that prevent aging.